Hepatocyte Nuclear Factor 4α Is a Central Regulator of Bile Acid Conjugation
نویسندگان
چکیده
منابع مشابه
Hepatocyte Nuclear Factor 4 Is a Central Regulator of Bile Acid Conjugation*
Hepatocyte nuclear factor 4 (HNF4 ) has an important role in regulating the expression of liver-specific genes. Because bile acids are produced from cholesterol in liver and many enzymes involved in their biosynthesis are preferentially expressed in liver, the role of HNF4 in the regulation of bile acid production was examined. In mice, unconjugated bile acids are conjugated with taurine by the...
متن کاملRegulation of bile acid biosynthesis by hepatocyte nuclear factor 4a
Hepatocyte nuclear factor 4a (HNF4a) regulates many genes that are preferentially expressed in liver. Mice lacking hepatic expression of HNF4a (HNF4a) exhibited markedly increased levels of serum bile acids (BAs) compared with HNF4a-floxed (HNF4a) mice. The expression of genes involved in the hydroxylation and side chain b-oxidation of cholesterol, including oxysterol 7ahydroxylase, sterol 12a-...
متن کاملRegulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver. Mice lacking hepatic expression of HNF4alpha (HNF4alphaDeltaL) exhibited markedly increased levels of serum bile acids (BAs) compared with HNF4alpha-floxed (HNF4alphaF/F) mice. The expression of genes involved in the hydroxylation and side chain beta-oxidation of cholesterol, including ...
متن کاملHepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.
Hepatocyte nuclear factor-4α (HNF4α) is known as the master regulator of hepatocyte differentiation. Recent studies indicate that HNF4α may inhibit hepatocyte proliferation via mechanisms that have yet to be identified. Using a HNF4α knockdown mouse model based on delivery of inducible Cre recombinase via an adeno-associated virus 8 viral vector, we investigated the role of HNF4α in the regulat...
متن کاملHepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.
OBJECTIVE Loss-of-function mutations in human hepatocyte nuclear factor 4α (HNF4α) are associated with maturity-onset diabetes of the young and lipid disorders. However, the mechanisms underlying the lipid disorders are poorly understood. In this study, we determined the effect of acute loss or augmentation of hepatic HNF4α function on lipid homeostasis. METHODS AND RESULTS We generated an ad...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m311015200